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MASH (Diet-Induced) | 加速させる、線維化研究を

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MASH (Diet-Induced)

dietinflammationliver

種

Mouse

期間

プロトコルID

M-cG9zdDoyMjc=

モデル概要

Models metabolic dysfunction-associated steatohepatitis (MASH) using high-fat, high-cholesterol diet.

方法論

主要評価項目

NAS score
Hepatic triglycerides
ALT/AST levels

関連文献

Angiopoietin-like protein 6 protects against methionine-choline deficient diet induced liver fibrosis by suppressing hepatic stellate cells activation via TGF-β1/Smad3 pathway.

Tang X, Wen S, Zhang J et al.

Int J Biol Macromol2026 Mar 19

Methionine and choline deficiency rewires transcriptional programs to recapitulate molecular features of human MASH.

You W, Ji J, Nguyen N et al.

J Lipid Res2026 Mar 17

Fecal microbiota transplantation alleviates steatosis and inflammation in high-fat and high-sugar diet-induced fatty liver in mice.

Mi F, Guo J, Zheng W et al.

Front Cell Dev Biol2026

Ginsenoside Rg1 alleviates MASH by targeting GLS2 to enhance PINK1/Parkin-mediated mitophagy and improve mitochondrial function.

Wang Z, Wang Y, Peng P et al.

Biochem Pharmacol2026 Mar 13

Multi-target mechanisms of Banxia Baizhu Tianma Decoction against MASH in a methionine-choline deficient mouse model: insights from a Multi-Omics Investigation.

Feng Q, Gao L, Shi J et al.

J Ethnopharmacol2026 Mar 12

PubMedで詳細を見る

Resmetirom (Rezdiffra)

Approved

resmetirom

Wegovy

Approved (MASH - FDA 2025)

Semaglutide

Zepbound

Phase 3

Tirzepatide

Survodutide

Phase 3

Survodutide

Efruxifermin

Phase 3

Efruxifermin

Lanifibranor

Phase 3

Lanifibranor

Pegozafermin

Phase 3

Pegozafermin

Denifanstat

Phase 3

Denifanstat

Retatrutide

Phase 3

Retatrutide

Pemvidutide

Phase 2b

Pemvidutide

Orforglipron

Phase 3

Orforglipron

VK2809

Phase 2b

VK2809