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Wegovy (Semaglutide) | 加速させる、線維化研究を

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Wegovy

Semaglutide

Approved (MASH - FDA 2025)

Sponsor: Novo Nordisk

Indication: MASH / Obesity

Mechanism of Action

GLP-1 Receptor Agonist

Target: GLP-1

Clinical Information

Approval Year

Clinical Trials (ClinicalTrials.gov)

RECRUITINGNCT05819138

Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes

Phase:PHASE3Org:University of Colorado, Denver

COMPLETED

Relevant Publications (PubMed)

Semaglutide ameliorates coronary microembolization-induced injury by suppressing apoptosis and inflammation via the HMGB1/RAGE/NF-κB p65 pathway.

Yang HF, Li HQ, Wang Q et al.

J Geriatr Cardiol2026 Feb 28

Efficacy and Safety of Cagrilintide and Cagrisema Versus Semaglutide as Anti-Obesity Medications: A Systematic Review, Meta-Analysis and Meta-Regression.

Ahmed M, Hassan M, Tahir M et al.

Diabetes Obes Metab2026 Mar 16

Semaglutide in patients with hidradenitis suppurativa and obesity.

Nicolau J, Sanchís P, Nadal A et al.

Med Clin (Barc)2026 Mar 12

Comparative effectiveness of semaglutide and dulaglutide combined with hypocaloric diet in newly diagnosed type 2 diabetes: a retrospective real-world study.

Validated Models

This drug has been validated in the following preclinical models:

NCT02172313

Effect of Food on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects

Phase:PHASE1Org:Novo Nordisk A/S

RECRUITINGNCT07251803

GLP1 Fasting Status and Gastric Retention Using Gastric Ultrasound

Org:Medical University of South Carolina

NOT_YET_RECRUITINGNCT07139405

TRIGLYTZA® VERSUS METFORMIN IN OBESE ADULT TYPE 2 DIABETES (T2DM) PATIENTS OVER 24 WEEKS OF TREATMENT

Phase:PHASE2Org:Myopharm Limited

RECRUITINGNCT06318442

The GAPSID Study - How GLP-1 Analogues Prevent Steroid-Induced Diabetes

Phase:NAOrg:Imperial College London

View all trials on ClinicalTrials.gov

Cetiner S

BMC Endocr Disord2026 Mar 14

Very Low Energy Ketogenic Diet vs Mediterranean Diet for MASLD: Superior Steatosis Reduction in a Randomised Pilot Study.

Farrell AM, Paris T, Parr EB et al.

JHEP Rep2026 Feb 19

View more on PubMed