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Pamrevlumab (pamrevlumab) | 加速させる、線維化研究を

Home/Drugs/Pamrevlumab

Pamrevlumab

pamrevlumab

Phase 3

Sponsor: FibroGen

Indication: IPF / Pancreatic Cancer

Mechanism of Action

Connective Tissue Growth Factor (CTGF) inhibitor

Target: CTGF

Clinical Information

Approval Year

Clinical Trials (ClinicalTrials.gov)

COMPLETEDNCT02210559

A Study of Gemcitabine Plus Nab-paclitaxel With or Without FG-3019 in Participants With Locally Advanced, Unresectable Pancreatic Cancer

Phase:PHASE1, PHASE2Org:FibroGen

COMPLETED

Relevant Publications (PubMed)

Breaking new ground in heart failure management: novel therapies and future frontiers.

Khalid A, Rodriguez P, Tasouli-Drakou V et al.

Front Cardiovasc Med2025

New Challenging Systemic Therapies for Juvenile Scleroderma: A Comprehensive Review.

Sassetti C, Borrelli C, Mazuy M et al.

Pharmaceuticals (Basel)2025 Apr 28

Minimum clinically important difference in Quantitative Lung Fibrosis score associated with all-cause mortality in idiopathic pulmonary fibrosis: subanalysis from two phase II trials of pamrevlumab.

Kim GH, Zhang X, Brown MS et al.

BMJ Open2025 May 12

"Regression to the truth": lessons learned from negative IPF trials.

Validated Models

This drug has been validated in the following preclinical models:

NCT01181245

A Phase 1 Study of Safety and Bioactivity With FG-3019 in Combination With Gemcitabine and Erlotinib for Subjects With Locally Advanced or Metastatic Pancreatic Cancer

Phase:PHASE1Org:FibroGen

COMPLETEDNCT05262309

An Open-label, Randomized, Parallel-arm Study Investigating the Efficacy and Safety of Intravenous Administration of Pamrevlumab Versus Standard of Care in Patients With COVID-19

Phase:PHASE2, PHASE3Org:Fondazione Policlinico Universitario Agostino Gemelli IRCCS

TERMINATEDNCT04419558

Zephyrus II: Efficacy and Safety Study of Pamrevlumab in Participants With Idiopathic Pulmonary Fibrosis (IPF)

Phase:PHASE3Org:FibroGen

TERMINATEDNCT02606136

Trial of Pamrevlumab (FG-3019), in Non-Ambulatory Participants With Duchenne Muscular Dystrophy (DMD)

Phase:PHASE2Org:FibroGen

View all trials on ClinicalTrials.gov

Trachalaki A, Lindahl AL, Petrarulo S et al.

Breathe (Sheff)2025 Apr

The latest developments in synthetic approaches to Duchenne muscular dystrophy.

Johnson LM, Pulskamp TG, Berlau DJ

Expert Rev Neurother2025 Feb 4

View more on PubMed