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UUO Mouse Model | Accelerate Your Fibrosis Research

Home/Models/UUO Mouse Model

UUO Mouse Model

fibrosiskidneysurge

Species

Mouse

Duration

Protocol ID

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Model Overview

Unilateral ureteral obstruction (UUO) model induces progressive renal fibrosis through mechanical obstruction.

Methodology

Key Endpoints

Histological fibrosis score
Collagen deposition
TGF-β expression

Relevant Publications

Optimization of CaMKII inhibitory peptide with N-terminal fatty acid chain modification and its study on anti-kidney fibrosis.

Lei H, Feng X, Yang R et al.

Bioorg Med Chem2026 Mar 16

Erythropoietin alleviate obstructive renal fibrosis by regulating immunity and inflammation through miR-21-5p/SPRY1/ERK1/2/NF-κB pathway inhibition.

Liu E, Sun X, Liu Q et al.

Front Mol Biosci2026

Ligustilide Alleviates Renal Fibrosis Through Fblim1-Dependent Inhibition of the TGF-β1/Smad3 Signaling Pathway.

Mushuo Q, Li J, Yang S et al.

Phytother Res2026 Mar 16

Activated platelets promote endothelial dysfunction and monocyte recruitment in early renal microvascular injury.

Rustiasari UJ, Uil M, Zhang X et al.

J Inflamm (Lond)2026 Mar 11

Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation.

Wang W, Gao Y, Chen Y et al.

Ren Fail2026 Dec

View more on PubMed

Related Drugs

Pamrevlumab

pamrevlumab