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Transverse Aortic Constriction (TAC) | Accelerate Your Fibrosis Research

Home/Models/Transverse Aortic Constriction (TAC)

Transverse Aortic Constriction (TAC)

fibrosisheartsurgical

Species

Mouse

Duration

4

Protocol ID

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Model Overview

Pressure overload model mimicking hypertensive heart disease and aortic stenosis.

Methodology

Key Endpoints

Left ventricular hypertrophy
Interstitial fibrosis
Ejection fraction

Relevant Publications

Suppressor of variegation 3-9 homolog 1 deficiency attenuates cardiac fibrosis and rescues heart failure through TACC2.

Zhu C, Xue Y, Hong W et al.

Cardiovasc Res2026 Mar 20

Integrated spatial transcriptomics and single-cell RNA sequencing reveal Lars2-mediated spatiotemporal dynamics of myocardial remodeling in a mouse model of transverse aortic constriction.

Ni H, Liang F, Huo H et al.

Front Immunol2026

Deletion of Cd248 in Postn (+) myofibroblast fails to attenuate pressure-overload induced cardiac remodeling and fibrosis in mice.

Li D, Zhong D, Tan T et al.

J Mol Cell Cardiol Plus2026 Mar

[Study on mechanism of Jiedu Huxin Formula protecting against heart failure caused by hypertension by regulating TGF-β1/p38 MAPK/NF-κB pathway based on network pharmacology and experimental validation].

He JL, Xu JL, Yue JW et al.

Zhongguo Zhong Yao Za Zhi2026 Feb

Modified hTERT treatment ameliorates pressure overload-induced heart failure.

Zhao Y, Bao X, Xiong W et al.

EBioMedicine2026 Mar 9

View more on PubMed