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Isoproterenol-Induced Cardiac Fibrosis | Accelerate Your Fibrosis Research

Home/Models/Isoproterenol-Induced Cardiac Fibrosis

Isoproterenol-Induced Cardiac Fibrosis

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Species

Mouse

Duration

2

Protocol ID

M-cG9zdDoyMzQ=

Model Overview

Model of cardiac hypertrophy and fibrosis driven by chronic beta-adrenergic stimulation.

Methodology

Key Endpoints

Heart weight/Body weight ratio
Interstitial fibrosis
Echocardiography

Relevant Publications

Cuminaldehyde, a natural monocyclic terpenoid, attenuates isoproterenol-induced myocardial infarction in rats via modulation of Bax/Bcl-2/Bcl-xL/Cyt.c/caspase- 9/caspase-3, and MMP-2/MMP-9 pathways.

Stanely SP, Issac R

Naunyn Schmiedebergs Arch Pharmacol2026 Mar 14

Pelargonidin Inhibits Isoproterenol Induced Myocardial Fibrosis via Regulating Transforming Growth Factor-beta/Smad2/3 Signaling and Th2 Cytokines in Mice.

Zhao J, Dong L, Yao L

Physiol Res2026 Mar 11

Phosphocreatine attenuates isoproterenol-induced cardiac fibrosis via activation of the Nrf2/ARE antioxidant pathway and preservation of endothelial integrity.

Liu W, Qaed E, Aldahmash W et al.

Arch Biochem Biophys2026 May

Protective Effects of Panax ginseng Extract on Endothelin-1- and Isoproterenol-Induced Cardiac Hypertrophy via Maintenance of Mitochondrial Function and Calcium-Reactive Oxygen Species (ROS) Homeostasis.

Tagashira H, Abe F, Yoshizaki M et al.

Cureus2025 Dec

Atrial TRPM2 Channel-Mediated Ca(2+) Influx Regulates ANP Secretion and Protects Against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis.

Numata T, Tagashira H, Sato-Numata K et al.

Cells2025 Dec 22

View more on PubMed