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Insights & Research

Latest updates on fibrosis research, biomarkers, and drug development trends.

Wnt/β-catenin: Why Does a 'Developmental Pathway' Cause Fibrosis? Bridging Regeneration and Drug Discovery

The developmental program that builds fetal organs, when reactivated in adults, can trigger fibrosis. Why does 'Wnt reactivation' occur in mature tissue? We explore TGF-β crosstalk and the Wnt pathway's potential as a drug target.

Inflammation-to-Fibrosis Tipping Point: Drug Window

When does chronic inflammation cross into fibrosis? We decode M1→M2 macrophage polarization, TGF-β duality, and EMT to identify the optimal window for therapeutic intervention.

Inflammation and Resolution: Mechanisms of Chronicity

Inflammation is not just defense—it is a step toward tissue repair. We explain acute inflammation initiation, active resolution via SPMs and efferocytosis, and transition to chronicity.

Fibrosis Mechanisms: Myofibroblasts as Drug Targets

Why do anti-fibrotic drugs keep failing? The answer lies in myofibroblast control. We cover TGF-β signaling, mechanotransduction, and key targets for fibrosis drug discovery.

Myofibroblast Origins and Activation: Drug Target Guide

Why do myofibroblasts persist and drive fibrosis instead of dying after wound healing? We explore origins (resident, pericyte, EMT) and survival signals to identify drug targets.

Anti-fibrotic Drugs 2026: IPF, MASH & Renal Fibrosis List

2026 antifibrotic drugs list: approved therapies (Pirfenidone, Nintedanib, Resmetirom) and Phase 2/3 pipeline candidates for IPF, MASH, renal fibrosis.

Fibrosis Biomarkers: KL-6, SP-D, and ELF Score Guide

Non-invasive biomarkers are critical for fibrosis diagnosis and monitoring. We cover KL-6, SP-D, ELF Score, and hyaluronic acid across lung, liver, heart, and kidney fibrosis.