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Wegovy (Semaglutide) | Accelerate Your Fibrosis Research

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Wegovy

Semaglutide

Approved (MASH - FDA 2025)

Sponsor: Novo Nordisk

Indication: MASH / Obesity

Mechanism of Action

GLP-1 Receptor Agonist

Target: GLP-1

Clinical Information

Approval Year

Clinical Trials (ClinicalTrials.gov)

COMPLETEDNCT03596450

Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic Trial

Phase:PHASE4Org:Novo Nordisk A/S

UNKNOWNNCT06339086

Efficacy and Safety of Semaglutide Injection in Subjects With Type 2 Diabetes

Phase:PHASE3Org:Chengdu Brilliant Pharmaceutical Co., Ltd.

NOT_YET_RECRUITINGNCT06987669

Gastric Emptying in Healthy Volunteers and GLP-1 Agonist Users

Org:Clinica Alemana de Santiago

NOT_YET_RECRUITINGNCT07030621

Efficacy of Semaglutide in Improving Neurological Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke: A Randomized Double-Blind Controlled Trial

Phase:PHASE3Org:RenJi Hospital

RECRUITINGNCT06396416

Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2

Phase:PHASE4Org:Western University, Canada

View all trials on ClinicalTrials.gov

Relevant Publications (PubMed)

Glucagon-Like Peptide-1 Receptor Agonists and Ocular Outcomes: Metabolic Transition, Retinal Vulnerability, and Risk-Stratified Monitoring.

Song SJ, Kim E

J Obes Metab Syndr2026 Apr 30

The Effects of New Antidiabetic Drugs on the Course of Peripheral Arterial Occlusive Disease.

Kröger K, Böhner H, Behrendt CA et al.

Dtsch Arztebl Int2026 May 29

Semaglutide for treatment of intractable diarrhea of different etiologies: a case series of 30 patients.

Nielsen GL, Hellström PM, Olesen SS et al.

Scand J Gastroenterol2026 Apr 29

GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.

Liskiewicz D, Novikoff A, Khalil A et al.

Nature2026 Apr 29

Semaglutide and Effort-Based Decision-Making in Major Depressive Disorder: A Randomized Clinical Trial.

Gill H, Badulescu S, Shah H et al.

JAMA Psychiatry2026 Apr 29

View more on PubMed

Validated Models

This drug has been validated in the following preclinical models: